Islamic World.
Ibn Al-Nafis(1213-1288 C.E.)
IBN AL-NAFĪS AND PULMONARY TRANSIt
His complete name is Ala-al-din abu Al-Hassan Ali ibn
Abi-Hazm al-Qarshi al-Dimashqi (Arabic: علاء
الدين أبو الحسن عليّ
بن أبي حزم القرشي
الدمشقي ), known as Ibn
al-Nafis (Arabic: ابن النفيس ), was an Arab physician
who is mostly famous for being the first to describe the Pulmonary Circulation
of the Blood.
He was born in 1213 in Damascus. He attended the Medical
College Hospital (Bimaristan Al-Noori) in Damascus. Apart from medicine, Ibn
al-Nafis learned Jurisprudence, Literature and He became an expert on the
Shafi’i school of Jurisprudence and an expert Physician
, Al-Nafis moved to Egypt. He worked at the Al-Nassri
Hospital, and subsequently at the Al-Mansouri Hospital, where he became chief
of physicians and the Sultan’s personal physician. When he died in 1288, he
donated his house, library and clinic to the Mansuriya Hospital.
The most voluminous of his books is Al-Shamil fi al-Tibb,
which was planned to be an encyclopedia comprising 300 volumes, but was not
completed as a result of his death. The manuscript is available in Damascus.His
book on Ophthalmology is largely an original contribution. His most famous
book is The Summary of Law (Mujaz al-Qanun). Another famous book, embodying his
original contribution, was on the effects of diet on health, entitled Kitab
al-Mukhtar fi al-Aghdhiya.His Al-Risalah al-Kamiliyyah fil Siera al-Nabawiyyah,
translated in the West under the title Theologus Autodidactus has been argued
to be both the first theological novel and the first science fiction novel.He
also wrote a number of commentaries on the topics of law and medicine. His
commentaries include one on Hipocrates‘ book, and several volumes on Ibn Sina’s
The Cannon of Medicine Additionally, he wrote a commentary on Ibn Hunayn
Ishaq’s book.
This great muslim scholar was died on17 December 1288
(aged 74–75) Cairo.
THEMES
Arabic Manuscripts
Sciences and Medicine
In the thirteenth century, Ibn al-Nafīs wrote a substantial
commentary on Avicenna’s entire Canon of Medicine thereby revising existing
understandings of human physiology and anatomy. His theory of the pulmonary
transit of blood formed a cornerstone of the modern theory of blood
circulation.
Galenic physiology and anatomy dominated the Arabic medical
tradition from the time of Ḥunayn
ibn Isḥāq (AD 809–873).
Medical authorities such as al-Rāzī (AD 865–c. 925) and al-Majūsī (died AD c.
982–994) innovated and critiqued medical practice, but seldom challenged the
underlying principles of the Galenic system. In his Canon of Medicine, Avicenna
(AD 980–1037) undertook the first rigorous attempt to align Galenic medicine
with a philosophically sound understanding of the nature of the living body,
and in so doing modified certain aspects of physiology. This led to Ibn
al-Nafīs’ devastating critique and reform of the entire basis of Galenic
medicine that laid the foundations for William Harvey’s (AD 1578-1657) theory
of blood circulation.
Ibn al-Nafīs’s
reforms were the result of two processes: an intensive theoretical study of
medicine, physics and theology in order to fully understand the nature of the
living body and its soul; and an attempt to verify physiological claims through
observation, including dissection of animals.
THE INVISIBLE PORES OF THE HEART
Galen had claimed that the septum (a muscle wall separating
the two sides of the heart) is porous, but since he could not see these pores
during dissection, he suggested they were so small they were invisible. Ibn
al-Nafīs harmonised theory and empirical observation in his proposal that blood
travelled from the right side to the left side of the heart via the lungs. This
is known as the pulmonary transit.
IBN AL-NAFĪS AND PULMONARY TRANSIT
THEMES
Arabic Manuscripts
Sciences and Medicine
In the thirteenth century, Ibn al-Nafīs wrote a substantial
commentary on Avicenna’s entire Canon of Medicine thereby revising existing
understandings of human physiology and anatomy. His theory of the pulmonary
transit of blood formed a cornerstone of the modern theory of blood
circulation.
Galenic physiology and anatomy dominated the Arabic medical
tradition from the time of Ḥunayn
ibn Isḥāq (AD 809–873).
Medical authorities such as al-Rāzī (AD 865–c. 925) and al-Majūsī (died AD c.
982–994) innovated and critiqued medical practice, but seldom challenged the
underlying principles of the Galenic system. In his Canon of Medicine, Avicenna
(AD 980–1037) undertook the first rigorous attempt to align Galenic medicine
with a philosophically sound understanding of the nature of the living body,
and in so doing modified certain aspects of physiology. This led to Ibn
al-Nafīs’ devastating critique and reform of the entire basis of Galenic
medicine that laid the foundations for William Harvey’s (AD 1578-1657) theory
of blood circulation.
Ibn al-Nafīs’s reforms were the result of two processes: an
intensive theoretical study of medicine, physics and theology in order to fully
understand the nature of the living body and its soul; and an attempt to verify
physiological claims through observation, including dissection of animals.
THE INVISIBLE PORES OF THE HEART
Galen had claimed that the septum (a muscle wall separating
the two sides of the heart) is porous, but since he could not see these pores
during dissection, he suggested they were so small they were invisible. Ibn
al-Nafīs harmonised theory and empirical observation in his proposal that blood
travelled from the right side to the left side of the heart via the lungs. This
is known as the pulmonary transit.
Beginning of Galen’s description of the anatomy of the veins
from the Arabic version of his De anatomicis administrationibus. Or. 9202, f.
122r
According to Galen, the veins were responsible for
distributing blood and the humours (i.e. nourishment) to the entire body, and the
arteries for distributing the vital spirit. This spirit was generated in the
left side of the heart from concocted air received from the lungs. The two sets
of vessels comprised two distinct systems, each governed by a separate organ,
and each possessing its own soul (or part of soul) that gave the necessary
powers to its respective organ.
The veins were part of the system of nutrition that was
governed by the liver, which received the powers of nourishment from the
nutritive soul. The arteries were concerned with distributing the spirit and
heat from the heart, which received its powers from the passionate soul. Galen
also believed that some less dense parts of the body could not be nourished by
the thick blood of the veins. He therefore suggested the existence of invisible
pores in the heart’s septum to allow for some blood to mix with the air and
spirit found in the left side of the heart, refining the blood enough to
nourish these parts of the body.
THE SOUL HAS NO PARTS: THE SEPTUM HAS NO PORES
On philosophical grounds, Ibn al-Nafīs rejected the claim
that the soul (nafs) had parts. Physiologically, he considered the heart
responsible for generating the spirit (rūḥ)
and introducing movement into the body. He then claimed that the septum could
not possess invisible pores, since the thick blood of the veins would then
corrupt the fine texture of the spirit, and suggested that the blood from the
right side was taken up by the lungs.
The beginning of Ibn al-Nafīs’s Commentary on the Anatomy of
the Canon. Or. 5596, f. 1v
In the lungs, some blood was filtered through the two tunics
(coverings) of the vessel that brought blood to the lungs from the heart. Ibn
al-Nafīs called this vessel the ‘artery-like vein’, but we now call it the
pulmonary artery. The filtered blood passed into the open spaces of the lungs,
where it mixed with air and was then absorbed by the ‘vein-like artery’
(pulmonary vein). This light, air-blood mixture generated the spirit in the
left side of the heart, while the thicker blood remaining in the pulmonary
artery nourished the lungs.
This new physiology and anatomy also led Ibn al-Nafīs to
reject Galen’s belief that the pulse was caused by a power that resided in the
arteries’ tunics, which caused all arteries to contract and expand simultaneously.
Instead, he claimed that the pulse was a direct result of the heartbeat, even
observing that the arteries contracted and expanded at different times
depending upon their distance from the heart. He also correctly identified that
the arteries contract when the heart expands, and expand when the heart
contracts.
TRANSIT AND CIRCULATION
According to Ibn al-Nafīs, the blood was entirely used up
during its journey through the body, and only a small part of the blood
participated in the pulmonary transit. Yet, the new physiology that supported
this anatomical theory was often discussed in later Arabic commentaries on
Avicenna’s Canon and Ibn al-Nafīs’s Concise Book on Medicine.
Some of these texts, such as Quṭb al-Dīn al-Shīrāzī’s (AD 1236-1311) Commentary
on the Canon, were read in Latin translation by Renaissance anatomists. Realdo
Colombo (AD 1519–1559), for example, used anatomical observations to defend
theories of the pulmonary transit and of the heart as the cause of the arterial
pulse. These two theories then provided the basis for Harvey’s modern theory of
blood circulation.
SECONDARY SOURCES
Nahyan Fancy, Science and Religion in Mamluk Egypt: Ibn
al-Nafīs, Pulmonary Transit and Bodily Resurrection (London: Routledge, 2013)
Nahyan Fancy, 'Medical Commentaries: A Preliminary
Examination of Ibn al-Nafīs’s Shurūḥ,
the Mūjaz and Commentaries on the Mūjaz' Oriens 41 (2013): 525-545
Beginning of Galen’s description of the anatomy of the veins
from the Arabic version of his De anatomicis administrationibus. Or. 9202, f.
122r
According to Galen, the veins were responsible for
distributing blood and the humours (i.e. nourishment) to the entire body, and
the arteries for distributing the vital spirit. This spirit was generated in
the left side of the heart from concocted air received from the lungs. The two
sets of vessels comprised two distinct systems, each governed by a separate
organ, and each possessing its own soul (or part of soul) that gave the
necessary powers to its respective organ.
The veins were part of the system of nutrition that was
governed by the liver, which received the powers of nourishment from the
nutritive soul. The arteries were concerned with distributing the spirit and
heat from the heart, which received its powers from the passionate soul. Galen
also believed that some less dense parts of the body could not be nourished by
the thick blood of the veins. He therefore suggested the existence of invisible
pores in the heart’s septum to allow for some blood to mix with the air and
spirit found in the left side of the heart, refining the blood enough to
nourish these parts of the body.
THE SOUL HAS NO PARTS: THE SEPTUM HAS NO PORES
On philosophical grounds, Ibn al-Nafīs rejected the claim
that the soul (nafs) had parts. Physiologically, he considered the heart
responsible for generating the spirit (rūḥ)
and introducing movement into the body. He then claimed that the septum could
not possess invisible pores, since the thick blood of the veins would then
corrupt the fine texture of the spirit, and suggested that the blood from the
right side was taken up by the lungs.
The beginning of Ibn al-Nafīs’s Commentary on the Anatomy of
the Canon. Or. 5596, f. 1v
In the lungs, some blood was filtered through the two tunics
(coverings) of the vessel that brought blood to the lungs from the heart. Ibn
al-Nafīs called this vessel the ‘artery-like vein’, but we now call it the
pulmonary artery. The filtered blood passed into the open spaces of the lungs,
where it mixed with air and was then absorbed by the ‘vein-like artery’
(pulmonary vein). This light, air-blood mixture generated the spirit in the
left side of the heart, while the thicker blood remaining in the pulmonary
artery nourished the lungs.
This new physiology and anatomy also led Ibn al-Nafīs to
reject Galen’s belief that the pulse was caused by a power that resided in the
arteries’ tunics, which caused all arteries to contract and expand
simultaneously. Instead, he claimed that the pulse was a direct result of the
heartbeat, even observing that the arteries contracted and expanded at
different times depending upon their distance from the heart. He also correctly
identified that the arteries contract when the heart expands, and expand when
the heart contracts.
TRANSIT AND CIRCULATION
According to Ibn al-Nafīs, the blood was entirely used up
during its journey through the body, and only a small part of the blood
participated in the pulmonary transit. Yet, the new physiology that supported
this anatomical theory was often discussed in later Arabic commentaries on
Avicenna’s Canon and Ibn al-Nafīs’s Concise Book on Medicine.
Some of these texts, such as Quṭb al-Dīn al-Shīrāzī’s (AD 1236-1311) Commentary
on the Canon, were read in Latin translation by Renaissance anatomists. Realdo
Colombo (AD 1519–1559), for example, used anatomical observations to defend
theories of the pulmonary transit and of the heart as the cause of the arterial
pulse. These two theories then provided the basis for Harvey’s modern theory of
blood circulation.
Discovering Pulmonary Circulation
The pulmonary circulation according to Ibn Al-Nafis.
The discovery of the pulmonary circulation is an interesting
and much debated topic. It is commonly believed that this discovery had its
inception in Europe in the sixteenth century by Servetus, Vesalius, Colombo,
and finally Harvey.
However, in view of the discovery of ancient manuscripts, it
is proposed that the real credit for the discovery of the pulmonary circulation
belongs to an eminent physician of the thirteenth century: Ibn Al-Nafis.
In 1924 an Egyptian physician, Dr. Muhyo Al-Deen Altawi,
discovered a script titled, "Commentary on the Anatomy of Canon of
Avicenna" in the Prussian state library in Berlin while studying the
history of Islamic Medicine at the medical faculty of Albert Ludwig’s
University in Germany.
This script is considered one of the best scientific books
in which Ibn Al-Nafis covers in detail the topics of anatomy, pathology and
physiology. This discovery revealed an important scientific fact, which up to
then had been ignored: the first description of the pulmonary circulation.
The theory that was accepted prior to Ibn Al-Nafis was
placed by Galen in the second century, who had theorized that the blood
reaching the right side of the heart went through invisible pores in the
cardiac septum to the left side of the heart where it mixed with air to create
spirit and was then consequently distributed to the body.
According to Galen's views, the venous system was quite
separate from the arterial system, except when they came in contact through the
unseen pores (3). However, Ibn Al-Nafis, based on his knowledge in anatomy and
scientific thinking stated that, "...The blood from the right chamber of
the heart must arrive at the left chamber but there is no direct pathway
between them.
The thick septum of the heart is not perforated and does not
have visible pores as some people thought or invisible pores as Galen thought.
The blood from the right chamber must flow through the vena arteriosa
(pulmonary artery) to the lungs, spread through its substances, be mingled
there with air, pass through the arteria venosa (pulmonary vein) to reach the
left chamber of the heart and there form the vital spirit...”
Elsewhere in his book he said, "The heart has only two
ventricles ...and between these two there is absolutely no opening. Also
dissection gives this lie to what they said, as the septum between these two
cavities is much thicker than elsewhere. The benefit of this blood (that is in
the right cavity) is to go up to the lungs, mix with what is in the lungs of
air, then pass through the arteria venosa to the left cavity of the two
cavities of the heart...”
In describing the anatomy of the lungs, Ibn Nafis stated,
"The lungs are composed of parts, one of which is the bronchi, the second
the branches of the arteria venosa and the third the branches of the vena
arteriosa, all of them connected by loose porous flesh."
He then added, "... The need of the lungs for the vena
arteriosa is to transport to it the blood that has been thinned and warmed in
the heart, so that what seeps through the pores of the branches of this vessel
into the alveoli of the lungs may mix with what there is of air therein and
combine with it, the resultant composite becoming fit to be spirit when this
mixing takes place in the left cavity of the heart. The mixture is carried to
the left cavity by the arteria venosa." (4)
Another important contribution of Ibn Nafis that is rarely
mentioned is his postulation that the nutrition of the heart is extracted from
the small vessels passing through its wall, when he said "... Again his
(Avicenna's) statement that the blood that is in the right side is to nourish
the heart is not true at all, for the nourishment to the heart is from the
blood that goes through the vessels that permeate the body of the
heart..." (4) Ibn Al-Nafis was thus the first to put forward the concept
of the coronary circulation.
Europe’s Late Awakening
These important observations were not known in Europe until
300 years later when Andrea Alpago of Belluno translated some of Ibn Al-Nafis’
writings into Latin in 1547 (5). Later, Michael Servetus described the
pulmonary circulation in his theological book, "Christianismi
Restitutio", in 1553 and wrote, "...air mixed with blood is sent from
the lungs to the heart through the arterial vein; therefore, the mixture is
made in the lungs.
The bright color is given to the sanguine spirit by the
lungs, not by the heart." (6). It is worth mentioning that the Church
accused Servetus of heresy for opposing the teachings of Galen, and was
consequently -with his book -burnt at the stake. Andreas Vesalius described the
pulmonary circulation in his book "De Fabrica", in a manner similar
to Ibn Nafis' description.
An interesting observation is that in the first edition of
the book (1543), Vesalius agreed with Galen that the blood "... soaks
plentifully through the septum from the right ventricle into the left...” Then
in the second edition (1555) he omitted the above statement and wrote
instead..."I still do not see how even the smallest quantity of blood can
be transfused through the substance of the septum from the right ventricle to
the left..." (5). Another similar description was given by Realdus Colombo
in 1559 in his book "De re Anatomica" (6).
Then it was William Harvey who, in 1628, demonstrated by
direct anatomic observation in laboratory animals the movement of blood from
the right ventricle to the lung and then observed the blood returning to the
left side of the heart via the pulmonary vein and again he stated that he could
not find any pores in the interventricular septum. He wrote in his monograph,
"Exercitatio anatomica de motu cordis et sanguinis in animalibus":
"I began to think there was a sort of motion as in a circle.
I afterwards found true, that the blood is pushed by the
beat of the left ventricle and distributed through the arteries to the whole
body and back through the veins to the vena cava and then returned to the right
auricle, just as it is sent to the lungs through the pulmonary artery from the
right ventricle and returned from the lungs through the pulmonary vein to the
left ventricle, as previously described." (6) However, he did not
understand the physiology of the pulmonary circulation (dissipation of carbon
dioxide and replacement with oxygen), which was fully elucidated by Lavoisier
in the 18th century (3).
Views of Some Modern Historians
It may be useful to mention the views of a few modern
historians who reviewed the works of Ibn Nafis; Mieli said, "We believe
that henceforth it is fair to attribute the discovery of the pulmonary
circulation to Ibn Nafis who was a distant precursor of the physicians of the
sixteenth century Italian School and of William Harvey who, four centuries
later, described the whole of the pulmonary circulation in an accurate, clear
and definitive manner."
Max Meyrholf, a distinguished scholar of Arabic historical
medicine, stated: “... We have seen that Ibn Nafis, three centuries before
Colombo, had already noticed visible passages between the two types of
pulmonary vessels."
In the William Osler Medal Essay on the discovery of the
pulmonary circulation, Edward Coppola said, "...The theory of pulmonary
circulation propounded by Ibn Nafis in the 13th century was not forgotten and
that centuries after his death it may have influenced the direction of the
anatomical investigations of Colombo and Valverde, who finally announced it to
the Western world as a physiological fact susceptible to experimental
proof." (5)
Sami Haddad (4) from Lebanon published an article in the
Annals of Surgery in 1936 about Ibn Nafis and other articles were published
also by Ayman et al and Dr. Abdul Kareem Shahadah from Syria showing clearly
that Ibn Al-Nafis should be given the credit for the discovery of the pulmonary
circulation 300 years before William Harvey was even born!
SECONDARY SOURCES
Nahyan Fancy, Science and Religion in Mamluk Egypt: Ibn
al-Nafīs, Pulmonary Transit and Bodily Resurrection (London: Routledge, 2013)
Nahyan Fancy, 'Medical Commentaries: A Preliminary
Examination of Ibn al-Nafīs’s Shurūḥ,
the Mūjaz and Commentaries on the Mūjaz' Oriens 41 (2013): 525-545
Ar Razi (865-925) dokter muslim yang pertama medeskripsi
dengan jelas cacar dan campak serta menduga akan merangsang timbulnya
kekebalan.
Cendekiawan Muslim di Abad Pertengahan Di antara abad ke 9
dan 14, para ilmuwan dari umat Muslim yang menguasai ilmu kimia, kedokteran,
astronomi, matematika, ilmu bumi dan banyak lagi lainnya, tidak saja telah
menghidupkan kembali disiplin ilmu bangsa Yunani, tetapi juga telah memperluas
cakrawalanya dengan meletakkan dan memperkuat fondasi di atas mana pengetahuan
modern bertumpu. (Stewart, 1967).
Ala-al-Din Abu al-Hasan Ali Ibn Abi al-Hazm al-Qarshi al-
Damashqi alMisri was born in 607 A.H. of Damascus. He was educated at the
Medical College-cum-Hospital founded by Nur al- Din Zangi. In medicine his
teacher was Muhaththab al-Din Abd al- Rahim. Apart from
medicine, Ibn al-Nafis learnt jurisprudence, literature and theology. He thus became
a renowned expert on Shafi'i School of Jurisprudence as well as a reputed
physician.
After acquiring his expertise in medicine and jurisprudence,
he moved to Cairo where he was appointed as the Principal at the famous Nasri
Hospital. Here he imparted training to a large number of medical specialists,
including Ibn al-Quff al-Masihi, thefamous surgeon. He also served at the
Mansuriya School at Cairo.
When he died in 678 A.H. he donated his house, library and
clinic to the Mansuriya Hospital.
His major contribution lies in medicine. His approach
comprised writing detailed commentaries on early works, critically evaluating
them and adding his own original contribution. Hlis major original contribution
of great significance was his discovery of the blood's circulatory system,
which was re-discovered by
modern science after a lapse of three centuries. He was the
first to correctly describe the constitution of the lungs and gave a description
of the bronchi and the interaction between the
human body's vessels for air and blood. Also, he elaborated
the function of the coronary arteries as feeding the cardiac muscle.
The most voluminous of his books is Al-Shamil fi al-Tibb, which
was designed to be an encyclopaedia comprising 300 volumes, but it could not be
completed due to his death. The manuscript is available at Damascus. His book
on ophthalmology is largely an original contribution and is also extant.
However, his book that became most famous was Mujaz al-Qanunand a number of
commentaries were written on this. His own commentaries include one on
Hippocrates' book. He wrote several volumes on Ibn Sina's Qanun, that are still
extant. Likewise he wrote
a commentary on Hunayn Ibn Ishaq's book. Another famous book
embodying his original contribution was on the effects of diet on health
entitled Kitab al-Mukhtar fi al-Aghdhiya. Ibn Al-Nafis' works integrated the
then existing medical knowledge and enriched it, thus exerting great influence
on the development of medical science, both in the East and the West.
However, only one of his books was translated into Latin at
early stages and, therefore, a part of his work remained unknown to Europe for
a long time.
He treatise The Concise Book (Kitab Mujiz) which epitomized
the Canon of Ibn Sina. The undated copy, written in a fine professional hand
with an illuminated heading and opening text in cloud bands, was probably
produced in Iran or India in the 17th to 18th century. NLM MS A44.1, fol. 1b
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